Frequency of the most common manifestations of local injection-site reactions, by dose, were swelling (18% and 15%), erythema (18% and 20%), and pain (24% and 18%). GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. Moderna COVID-19 Vaccine is a monovalent COVID-19 vaccine that is authorized for emergency use to prevent COVID-19 as a: Two-dose primary series for individuals 6 months of age and. J Prim Care Community Health. Studies suggest that delayed skin reactions occurring days or a week after the shot may affect fewer than one in 100 people. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. The most common manifestations of localized injection-site reactions were swelling (44% after the first dose, 68% after the second), erythema (49% and 67%), and pain (35% and 59%). This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-moderna/information-for-uk-recipients-on-covid-19-vaccine-moderna, Spikevax dispersion for injection The source was a giant welt surrounding Hoang's injection site. COVID-19 vaccines protect against the SARS-CoV-2 virus only, so it's still important to keep yourself healthy and well. Among those who received the Moderna vaccine, delayed large local skin reactions were most common, occurring in 175 of 267 (66%) patients after the first dose and 31 of 102 (30%) after the. N Engl J Med. Symptoms may include: hives swelling wheezing or trouble breathing Some people get a rash at the injection. Calle del Prncipe de Vergara 132 Plt 12 If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. Charles Bankhead, Senior Editor, MedPage Today Opens in a new tab or window. eCollection 2022 Sep. Rodrguez Y, Rojas M, Beltrn S, Polo F, Camacho-Domnguez L, Morales SD, Gershwin ME, Anaya JM. If You Have a Skin Reaction to the Moderna COVID-19 Vaccine, Don't Panic. They have been observed more often after the second dose compared to the first dose, and more often in younger males. 2021 Nov 13;114(9):659-660. doi: 10.1093/qjmed/hcab161. Investigators identified no safety concerns and no evidence of vaccine-associated enhanced respiratory disease (VAERD). Moderna will build a centre in Harwell, Oxfordshire, to produce vaccines for Covid, flu and RSV (respiratory syncytial virus). Tel: 0800 085 7562. Is the COVID Vaccine Safe for People With Lung Cancer? Respiratory symptoms, including nasal discharge, nasal congestion, change in voice quality, stridor, cough, wheeze, and dyspnea. If you have previously had episodes of CLS, talk to a doctor before you are given Spikevax. sharing sensitive information, make sure youre on a federal News. * Approximation only. MB), Help with COVID-19 vasculitis and novel vasculitis mimics. Moderna's coronavirus vaccine may cause alarming delayed side effects from its first dose among a portion of recipients. This medicine is subject to additional monitoring. A survey of more than 40,000 healthcare employees at Mass General Brigham who received either the Moderna or Pfizer COVID-19 vaccines, found that 1.9% reported itching, rash, hives, or swelling after the first dose. doi:10.1056/NEJMoa2035389, Robinson LB, Fu X, Hashimoto D, et al. If you develop a reaction, the researchers recommend treatment with basic over-the-counter anti-allergy medications. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. This article will explore what skin reactions to the Moderna COVID-19 vaccine look like, how common they are, and what to do if you get one. The condition is harmless, but may be mistaken for an infection. This site needs JavaScript to work properly. If you miss an appointment, arrange another visit as soon as possible with your doctor, nurse, or pharmacist. We study millions of patients and 5,000 more each day. We have a lot of things that are delayed hypersensitivity, like eczema, contact dermatitis, common antibiotic rashes," Blumenthal says. You may need to read it again. Cellulitis staphylococcal is reported only by a few people who get Moderna COVID Vaccine. 2021 Elsevier Ltd. All rights reserved. Discuss appropriate individual recommendations with your The study said they were associated with younger patients, lasted for an average of 12.7 days, appeared later in the course of COVID-19 and were associated with less severe cases of the disease. Pruritic, painful, erythematous, indurated plaque at vaccine site in a 44-year-old woman (patient 2) 7days after first vaccine dose. Freeman disclosed a relevant relationship with UpToDate. doi: 10.1093/ofid/ofac499. Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2. FOIA Spikevax is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people from the age of 6 months. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. Among those who had a skin reaction after the first dose, 11 people also had a similar reaction after their second dose. Researchers suspect that delayed skin reactions to the Moderna vaccine are caused by an intense reaction by T-cells, a part of the immune system that attacks threats, that occurs at least 12 hours after receiving a dose. Incident systemic rheumatic disease following COVID-19. One area that may react to the vaccine is the arm where you received the shot. The vaccine was co-developed by Moderna, Inc., a biotechnology company based in Cambridge, Massachusetts, and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National . GC, GDL, SC, RP, FC, and LD took clinical care of patients, obtained data, and contributed to drafting the manuscript. Bookshelf series in individuals 18 years of age and older. image, Download .pdf (.47 Privacy PolicyTerms and ConditionsAccessibility, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy, Division of Rheumatology, Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University, Rome, Italy, Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. "I think this is particularly interesting because it shows that the body is mounting an immune response to the vaccine, just as it does after infection with the virus," said Freeman. Specifically, we would recommend taking an antihistamine such as fexofenadine or cetirizine and using a topical steroid for the itch, swelling, and redness," Saff says. Spikevax uses a substance called messenger ribonucleic acid (mRNA) to carry instructions that cells in the body can use to make the spike protein that is also on the virus. extensive swelling of the vaccinated limb, heavy menstrual bleeding (most cases appeared to be non-serious and temporary in nature). It can also develop around the eyes, mouth, and anus, or on the belly. Moderna's COVID-19 vaccine, also known as mRNA-1273, is a two-dose vaccine. Some reports may have incomplete information. Most of the reactions were mild and resolved on their own. upper arm. The company has forecast Covid vaccine sales of $5 billion for . With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. All rights reserved. The study was also limited to a single medical center during a short period of time. MODERNA BIOTECH SPAIN, S.L. Federal government websites often end in .gov or .mil. This vaccine contains polyethylene glycol/macrogol (PEG) as part of PEG2000-DMG. 2021 Jan-Dec;12:21501327211024431. doi: 10.1177/21501327211024431. We also use cookies set by other sites to help us deliver content from their services. As with any vaccine, the primary 2-dose vaccination course of Spikevax may not fully protect all those who receive it and it is not known how long you will be protected. In a letter to the editor published in The New England Journal of Medicine (NEJM) on March 3, 2021, researchers reported on a dozen people who developed skin redness, skin thickening and swelling, tenderness, or some combination of these symptoms at the injection site between four and 11 days after receiving their first dose of the Moderna COVID-19 vaccine. Reactions to the Moderna COVID-19 vaccine usually happen within 4 hours of injection. Spikevax contains elasomeran, a molecule called messenger RNA (mRNA) with instructions for producing a protein from the original strain of SARS-CoV-2, the virus that causes COVID-19. Well send you a link to a feedback form. Very large clinical trials have shown that Moderna is effective in preventing COVID-19 in people aged 12 years and older. Once the viral vector enters the body, immune cells then recognise . By contrast, 244 (0.8%) developed a delayed skin reactiondefined as a skin reaction that appears eight or more days laterafter getting their first dose, and 68 (0.2%) developed a delayed skin reaction after getting their second dose. Epub 2022 Aug 1. An additional overfill is included in each vial to ensure that 10 doses of 0.5 mL or a maximum of 20 Spikevax can be given during breastfeeding. Subcuta-neous injection can happen inadvertently (figure 1), affecting efficacy of vaccination and potentiate local adverse events. The doses are administered 28 days apart, and the vaccine trains the immune system to fight against future. If you do develop one, don't panic. In addition, you can report side effects to ModernaTX, Inc. at 1-866-663-3762. Normal skin can be affected by cellulitis, but it usually happens after some type of injury causes a skin break, including trauma or surgery. No other type of reaction occurred in more than 1%-2% of patients after either dose. This means that there is more evidence to come about this vaccine. These conditions can develop within just a few days after vaccination and have primarily occurred within 14 days. Australian health minister Greg Hunt in hospital with infection cellulitis after Covid vaccine | Daily Mail Online Grim details of Health Minister Greg Hunt's serious infection are. The authors noted that it's possible that redness gets overlooked or may not be as obvious on dark skin. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. THURSDAY, March 4, 2021 (HealthDay News) -- Some people given the Moderna COVID-19 vaccine may develop a reaction at the injection site that can first appear . We use some essential cookies to make this website work. Successful Treatment of Delayed Localized Necrotizing Inflammatory Myositis After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine: A Case Report. Vaccine Types. Worry over having a skin reaction should not deter you from getting a COVID-19 vaccine. Autoimmune and autoinflammatory conditions after COVID-19 vaccination. COVID Arm: Delayed Hypersensitivity Reactions to SARS-CoV-2 Vaccines Misdiagnosed as Cellulitis. The reactions were first observed during a phase 3 clinical trial of the Moderna vaccine. Pendlebury GA, Oro P, Haynes W, Merideth D, Bartling S, Bongiorno MA. Both the Pfizer and Moderna vaccines are approved for ages 6 months and older. Audio will be available later today. As a physician, I knew the possible side-effects of the new Moderna COVID-19 vaccine: fever, muscle pain, local redness, local swelling and axillary (arm pit) lymph nodes, but those were. Careers. Epub 2022 Jun 21. The recipient's health condition or recommendations for vaccination may change from one visit to the next. She has previously written for publications including Insider and Cancer Health. Less commonly, patients had episodes of zoster (shingles), herpes simplex flares, and rosacea-like reactions. The Covid-19 vaccine is one example of how mRNA can be used. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. The mRNA is embedded in SM-102 lipid nanoparticles. Key Points. stroking or scratching the skin), Menstrual disorder (disease of menstrual cycle), Menstruation delayed (late menstruation cycle), Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability), Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition), Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation), Micturition urgency (urgency to pass the urine), Mobility decreased (ability to move is reduced), Monoplegia (a paralysis of a single limb), Mood swings (an extreme or rapid change in mood), Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness), Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. The centre will create hundreds of jobs and make 100 million vaccines . Clinicians can distinguish SARS-CoV-2 vaccine reactions from cellulitis by the time of onset (approximately a week vs 5 days), by the lack of progression of symptoms, and resolution over 4 to 5 days. Severe cases of COVID arm may be treated with topical steroids. Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2. In: Mandell GL, Bennett JE, Dolin R. (eds) Principles and Practice of Infectious Diseases. A booster dose (0.25 mL) of Spikevax may be given at least 3 months after the second dose in 2021;157(6):716. doi:10.1001/jamadermatol.2021.1214, Lindgren AL, Austin AH, Welsh KM. SARS-CoV-2 infection has resulted in more than 4 million deaths worldwide, often due to excessive or aberrant host immune responses. There were 7 SAEs among 6 participants in the vaccine group (appendicitis, cellulitis, cellulitis orbital, type 1 diabetes mellitus, appendicitis, pyelonephritis and urosepsis). Written informed consent for publication was obtained from the patients. Dissecting cellulitis . While the coronavirus 2019 (COVID-19) vaccine is currently being rolled out, some vaccine recipients are experiencing adverse effects (AEs), one of which includes a delayed large local reaction. Ankylosing Spondylitis and the COVID Vaccine: Is It Safe? Swaetz M. Cellulitis and subcutaneous tissue infections. headache, muscle pain, joint pain. The JAMA Dermatology report included a broader age range of 25 to 89, with the majority of people also identified as White and female. However, laboratory tests showed only non-specific increases in erythrocyte sedimentation rate and C-reactive protein (CRP); anti-neutrophil cytoplasmic antibodies, cytoplasmic anti-neutrophil cytoplasmic antibodies, perinuclear anti-neutrophil cytoplasmic antibodies, rheumatoid factor, cryoglobulins, antinuclear antibodies, anti-DNA, C3, C4, IgA, and serology for hepatitis B virus and hepatitis C virus were negative or normal. However, the actual percentage is likely higher. 2022 Sep;21(9):3636-3650. doi: 10.1111/jocd.15261. He joined MedPage Today in 2007. Thawed vials and filled syringes can be handled in room light conditions. COVID arm: delayed hypersensitivity reactions to SARS-CoV-2 vaccines misdiagnosed as cellulitis. Received vaccine (at least 1 dose) 312 (94.8%) Moderna 122 (39.1% . Vaccines against SARS-CoV-2 represent a pivotal and effective countermeasure to contain the COVID-19 pandemic. You have rejected additional cookies. 2022 Jul 16;10(7):1135. doi: 10.3390/vaccines10071135. The expiry date refers to the last day of that month. 2021 Sep;20(9):2684-2690. doi: 10.1111/jocd.14312. The vaccine will be available to people aged 12 and older as a booster. By Steven ReinbergHealthDay Reporter. Eur Rev Med Pharmacol Sci. Berg S. What doctors wish patients knew about the Johnson & Johnson vaccine. A wide range of skin reactions has occurred following coronavirus vaccination -- including some that mimic COVID-19 symptoms -- but none proved to be serious, according to initial data from an international registry. Your doctor, pharmacist or nurse will inject the vaccine into a muscle (intramuscular injection) in your To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. Viruses. The study looked at Pfizer and Moderna jabs, which have the same messenger RNA process. It appears as a red, warm, pruritic, indurated, or swollen area in the vicinity of the vaccine site. Spikevax will be given to you as two 0.5 mL injections. 2021 Apr 13;22(1):276. doi: 10.1186/s13063-021-05180-1. National Library of Medicine Clipboard, Search History, and several other advanced features are temporarily unavailable. Hosseinzadeh A, Ebrahimi K, Shahriarirad R, Dalfardi F. Clin Case Rep. 2022 Dec 15;10(12):e6317. Departments, agencies and public bodies. Source Reference: McMahon DE, et al "Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases" J Am Acad Dermatol 2021; DOI: 10.1016/j.jaad.2021.03.092. DOI: https://doi.org/10.1016/S2665-9913(21)00309-X. J Autoimmun. J Prim Care Community Health. https://www.hhs.gov/immunization/basics/types/index.html. But patients will have to use the . Keep this vaccine out of the sight and reach of children. Pierce the stopper preferably at a different site each time. Spikevax will be given to you as two 0.25 mL injections. PMC As the Times notes, not only did Moderna make roughly $36 billion in sales from COVID-19 vaccines worldwide, the company also received $10 billion in taxpayer funding to help develop and test the . official website and that any information you provide is encrypted Of the 414 reactions documented, 83% occurred in patients vaccinated with the Moderna vaccine and 17% in patients who received the Pfizer vaccine. They were discussed during the recent AAD virtual meeting and published simultaneously in the Journal of the American Academy of Dermatology. 2021 Nov 4;165:D6313. Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis. Vaccines against SARS-CoV-2 represent a pivotal and effective countermeasure to contain the COVID-19 pandemic. The findings came from the COVID-19 Dermatology Registry, a joint effort of the American Academy of Dermatology (AAD) and the International League of Dermatologic Societies. It will take only 2 minutes to fill in. COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. For the primary series, Spikevax should be administered as two 0.5 mL (100 microgram) doses for individuals 12 years of age and older. Authors Sathishkumar Ramalingam 1 , Harkesh Arora 2 , Susan Lewis 2 , Kulothungan Gunasekaran 3 , Maheswari Muruganandam 4 , Sivakumar Nagaraju 2 , Priyesh Padmanabhan 5 Affiliations They vary in appearance and size and can sometimes cover most of the upper arm. They also stress that concerns about a skin reaction should not keep people from getting vaccinated. Madrid 28002 They give you the best protection against COVID-19. for at least 15 minutes to monitor for signs of an allergic reaction. It is recommended to get the second dose 28 days after the first dose to complete the vaccination course. These measures will help protect the environment. Magen E, Mukherjee S, Bhattacharya M, Detroja R, Merzon E, Blum I, Livoff A, Shlapobersky M, Baum G, Talisman R, Cherniavsky E, Dori A, Frenkel-Morgenstern M. Vaccines (Basel). Before The COVID-19 vaccine has shown to have high efficacy if given correctly intramuscularly. Cutaneous adverse reactions following COVID-19 vaccinations: A systematic review and meta-analysis. May 5, 2021. Eczema and the COVID-19 Vaccine: Is it Safe? All rights reserved. By Caroline Tien The site is secure. They were about 2.6 times as likely . Covid Vaccination Linked to 21% Average Increase in a Large Number of Medical Problems. Not uncommonly, skin reactions were accompanied by systemic effects, including fatigue, myalgia, headache, fever, arthralgia, nausea, and chills. -. For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder. An official website of the United States government. If you miss a scheduled injection, you may not be fully protected against COVID-19. A new study finds some of them, including COVID toes, a measleslike rash and shingles also can be rare, and thankfully brief, side . The active substance in Spikevax is mRNA encoding the SARS-CoV-2 Spike protein. This weakened animal virus is known as a 'viral vector'. "We have been involved with following skin reactions to COVID-19 vaccines, but the paper is pretty novel in that it covers a whole range of reactions that had not been reported from vaccine clinical trials," registry principal investigator Esther Freeman, MD, PhD, of Massachusetts General Hospital in Boston, told MedPage Today. Published 2021. Iqbal Yatoo M, Hamid Z, Parray OR, Wani AH, Ul Haq A, Saxena A, Patel SK, Pathak M, Tiwari R, Malik YS, Sah R, Rabaan AA, Rodriguez Morales AJ, Dhama K. Hum Vaccin Immunother. How well it works: Moderna's initial Phase 3 clinical data in December 2020 was similar to Pfizer-BioNTech'sat that point, both vaccines showed about 95% efficacy for prevention of COVID-19. As of Sept 23, 2021, more than 83 million vaccine doses were administered in Italy, with approximately a fifth of recipients receiving ChAdOx1 nCoV-19 vaccine. Chest imaging (ie, x-ray or CT), urinalysis, and a search for stool blood were also negative. According to the FDA,. Anti-SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis. ), unusual feeling in the skin, such as tingling or a crawling feeling (paraesthesia), Inflammation of the heart muscle (myocarditis) or inflammation of the lining outside the heart (pericarditis) which can result in breathlessness, palpitations or chest pain, Severe allergic reactions with breathing difficulties (anaphylaxis), Reaction of increased sensitivity or intolerance by the immune system (hypersensitivity). Rebecca Saff, MD, PhD, another lead author of the NEJM report and allergy fellowship director of the allergy and clinical immunology unit in the division of rheumatology, allergy, and immunology at Massachusetts General Hospital, tells Verywell that in the trial, "adverse events, including local adverse symptoms, were solicited for the seven days after the vaccine was given and unsolicited for 28 days after the vaccine, meaning that many of the more mild reactions may have been missed if they were after day seven.". 2021;157(8):1000. doi:10.1001/jamadermatol.2021.2114. The Lancet Regional Health Southeast Asia, The Lancet Regional Health Western Pacific, B cells: more than just for antibodies in SARS-CoV-2 vaccine responses, Haemophagocytic lymphohistiocytosis secondary to COVID-19: a case series, We use cookies to help provide and enhance our service and tailor content and ads. Common Moderna COVID-19 Vaccine side effects may include: fever, chills; redness or a hardness and swelling where the shot was given; swelling or tenderness under your arm; nausea, vomiting; feeling tired; or. Specifically, vasculitis developed in healthy individuals with no personal or family history of autoimmunity; clinical manifestations were similar and characterised by widespread cutaneous vasculitis with no visceral involvement; and there was a temporal association between vaccination and the development of clinical manifestations, with no other intercurrent inciting events. Interleukin 1alpha: a comprehensive review on the role of IL-1alpha in the pathogenesis and treatment of autoimmune and inflammatory diseases. Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity. Accessed April 28, 2021. Overview. Sixty-year-old woman (patient 1) 24h after initiation of topical steroid treatment; the left arm showed a dramatic decrease in erythema and swelling. PMC The mRNA COVID-19 vaccine is a lipid nanoparticle-encapsulated, nucleoside-modified mRNA vaccine that encodes the prefusion spike glycoprotein of the SARS-CoV-2 virus responsible for COVID-19. General side effects: fatigue, headache, muscle pain, joint pain, chills, nausea and vomiting, and fever. Subcutaneous injection can happen inadvertently ( figure 1 ), affecting efficacy of vaccination and potentiate local adverse events. lead to localised cellulitis, granuloma formation and abscess. Subcutaneous injections can lead to localised cellulitis, granuloma formation and abscess. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The vaccine was also effective in people aged 65 years and in adolescents aged 12 to 17 years. 2021:384(5). The federal government has granted companies. Moderna Inc will make certain contingent development, commercial and regulatory milestone payments to the U.S. National Institutes of Health (NIH) related to the development of COVID-19 vaccines . . To update your cookie settings, please visit the Cookie Preference Center for this site. There was also someone whose reaction was mistaken for cellulitis and treated with antibiotics noted in the JAMA Dermatology report of patients at Yale New Haven Hospital. If you are pregnant or think you may be pregnant, tell your doctor, nurse or pharmacist before you receive this vaccine. In a study published in the NEJM in February, 2021, the investigators reported that 12,765 (84.2%) of the 15,168 participants who had received the vaccine rather than the placebo developed an immediate skin reaction after receiving their first dose of the vaccine. News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. doctor. Erythematous, pruritic, painful, indurated plaque in a 33-year-old woman (patient 3) 7days after first dose of vaccine. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. The registry data included a total of eight cases of pernio/chilblains, three each after the first dose of both vaccines and two after the second Pfizer vaccine dose. by 2022 Jun 29;9(3):212-243. doi: 10.3390/dermatopathology9030027. "It was about eight centimeters big. American Medical Association. Some who . If you are immunocompromised, you may receive a third dose of Spikevax. Individuals should be observed by a healthcare professional for at least 15 minutes after vaccination. COVID arm that appeared in the contralateral upper extremity after mRNA-1273 booster inoculation. Please enable it to take advantage of the complete set of features! The vaccine also demonstrated efficacy in preventing severe COVID-19. FOIA Among people who had a skin reaction after the first dose and completed a survey after their second dose (609 people), 83% reported no skin reaction after their second shot. Or visit Moderna COVID-19 Global. government site. For the most recent updates on COVID-19, visit our coronavirus news page. However, the reactions' appearances can vary. 1 Local reactions include mild to moderate pain at the injection site, and systemic side effects like fatigue, headache, and fever have been common after
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